Planning on going above 3000m? For many, myself included as I live at sea level, this can present significant problems. As I usually don’t have as much time for acclimatization due to work constraints, this paper helped me determine what the best dose of acetazolamide is for prevention of acute mountain sickness.
In their analysis, they found a fair amount of attrition due to this study being limited to non-native, non hypobaric studies (ie, people who actually went to the mountains and weren’t from there). Final determination was that the lowest dose of 250mg studied had the least side effects, but also needed a higher number needed to treat than the highest dose of 750mg.
“Identifying the lowest effective dose of acetazolamide for the prophylaxis of acute mountain sickness:
systematic review and meta-analysis.”
Sadly, they didn’t study lower doses than the 250mg, so no way to see if there is a lower effective dose from this study. However, other authors feel that it is time to stop studying acetazolamide against placebo, and instead start doing combination drug studies. I can’t say I disagree.
“Acetazolamide for the Prevention of Acute Mountain Sickness: Time to Move On”